The short answer
Based on available data, the Acura MDX comes out ahead of the Infiniti QX60 on power. Check the specs table and owner sentiment below for the full comparison before deciding between the two. Both are covered by real owner reports on CarWizz.
Overall
Overwhelmingly positive sentiment for first-generation model, widely regarded as groundbreaking luxury three-row SUV establishing segment template and Honda reliability reputation. Praised extensively for exceptional longevity with examples routinely exceeding 250,000-300,000 miles (402,000-483,000 km), comfortable ride quality, spacious three-row seating accommodating adults, powerful 3.5L V6 engine (240-265 hp depending on year), and low maintenance costs typical of Honda engineering. Owners report emotional attachments spanning 15-20+ years and multiple hundred thousand miles, describing MDX as "best vehicle ever owned" and "family member." However, criticism includes outdated technology by modern standards (no Bluetooth, basic infotainment in early years), thirsty fuel consumption (16-19 MPG combined), transmission issues affecting some high-mileage examples beyond 200,000 miles, and typical Honda third-row tightness for adults.
Best version to buy
3.5L V6 with Technology Package (2004-2006) The 2004-2006 model years preferred for revised 265 hp engine (versus 240 hp 2001-2003), improved transmission calibration addressing early issues, and Technology Package adding navigation, rear entertainment, premium audio. The SH-AWD (Super Handling All-Wheel Drive) system standard across all trims providing excellent winter traction and handling dynamics. 2005-2006 final years represent most refined iteration before second-generation redesign.
Known issues
Overall
Sentiment is sharply divided by model year and generation, with reliability being the dominant theme. For the first-generation models (approximately 2014-2021), sentiment is overwhelmingly negative due to widespread, severe transmission failures associated with the CVT (Continuously Variable Transmission). These failures are described as catastrophic, often occurring between 20,000 and 120,000 miles, with repair costs equaling or exceeding the vehicle's value.
Best version to buy
For the second generation (2022+), the Autograph trim is mentioned as being well-equipped and desirable. For the first generation, no specific trim is recommended due to the overarching transmission concerns.
Known issues
The verdict
The Acura MDX is the better choice for most buyers.
It has more power on its best-equipped version than the Infiniti QX60, based on the data above. If efficiency matters more to you than outright power, the Infiniti QX60 is worth a closer look instead.
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Which is more reliable, the Acura MDX or the Infiniti QX60?
Owner reports show similar reliability sentiment for the Acura MDX and the Infiniti QX60. Check the known issues listed above for specific differences between the two.
Which is better for families, the Acura MDX or the Infiniti QX60?
Data on family-specific factors like cargo space is limited for one or both models, but based on available reports, both are positioned as practical daily drivers. Check the specs table above for seating and body type.
Which has better fuel economy, the Acura MDX or the Infiniti QX60?
Fuel consumption data is limited for one or both models. Check the specs table above for the figures available on each catalogued version.
Which is cheaper to maintain, the Acura MDX or the Infiniti QX60?
Exact maintenance costs aren't in our data, but owner reports mention cost-related concerns more often for the Infiniti QX60 than the Acura MDX. See the known issues comparison above.