The short answer
Based on available data, the Acura MDX comes out ahead of the Infiniti QX60 on power. Check the specs table and owner sentiment below for the full comparison before deciding between the two. Both are covered by real owner reports on CarWizz.
Overall
Owners broadly praise the MDX for reliability, driving dynamics, interior comfort, and value, with many describing it as the most reliable vehicle they have owned and reporting zero issues over tens of thousands of miles. The most consistent criticisms are poor fuel economy (especially on the Type S and in city driving), interior creaks and rattles, glitchy infotainment software, and frustrating dealer service experiences. The 3.5-liter V6 is widely regarded as exceptionally durable, while the Type S turbo V6 draws mixed feedback on reliability, with a few owners reporting serious electrical and mechanical failures.
Best version to buy
Insufficient owner data available to declare a consensus. The 3.5-liter V6 (non-Type S) draws the strongest reliability praise, with multiple owners calling it "God-tier" and "bulletproof," while the Type S turbo V6 has both strong defenders and a few reports of serious failures.
Known issues
Overall
Sentiment is sharply divided by model year and generation, with reliability being the dominant theme. For the first-generation models (approximately 2014-2021), sentiment is overwhelmingly negative due to widespread, severe transmission failures associated with the CVT (Continuously Variable Transmission). These failures are described as catastrophic, often occurring between 20,000 and 120,000 miles, with repair costs equaling or exceeding the vehicle's value.
Best version to buy
For the second generation (2022+), the Autograph trim is mentioned as being well-equipped and desirable. For the first generation, no specific trim is recommended due to the overarching transmission concerns.
Known issues
The verdict
The Acura MDX is the better choice for most buyers.
It has more power on its best-equipped version than the Infiniti QX60, based on the data above. If efficiency matters more to you than outright power, the Infiniti QX60 is worth a closer look instead.
Common problems by model year
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Owner reports show similar reliability sentiment for the Acura MDX and the Infiniti QX60. Check the known issues listed above for specific differences between the two.
Data on family-specific factors like cargo space is limited for one or both models, but based on available reports, both are positioned as practical daily drivers. Check the specs table above for seating and body type.
The EPA rates the 2026 Acura MDX at 19–22 mpg combined and the 2027 Infiniti QX60 at 24 mpg, depending on the version.
Exact maintenance costs aren't in our data, but owner reports mention cost-related concerns more often for the Infiniti QX60 than the Acura MDX. See the known issues comparison above.